Ion conduction and selectivity in the ryanodine receptor channel.
نویسنده
چکیده
The ryanodine receptor channel is an intracellular membrane Ca2+-release channel. The investigation of ion translocation and discrimination in individual channels under voltage-clamp conditions has revealed that the channel can sustain very high rates of cation translocation, has high affinity for divalent cations and displays relatively poor discrimination between physiologically relevant cations. In this article I will discuss the mechanisms underlying these characteristic properties, the regions of the channel molecule likely to be involved in ion handling and speculate on the structure of the conduction pathway of Ca2+-release channels.
منابع مشابه
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عنوان ژورنال:
- Frontiers in bioscience : a journal and virtual library
دوره 7 شماره
صفحات -
تاریخ انتشار 2002